Spectrophotometric Determination of Carvedilol Via Oxidative Coupling Reaction Using Leichmanns Dye

Abstract

A sensitive spectrophotometric method has been developed for the determination of carvedilol in both pure form and pharmaceutical prerarations. This method based on the oxidative coupling reaction of carvedilol (CAR) with the Leichmann dye in the presence of ceric (IV) sulphate as the oxidizing agent in an acidic medium forming a colored product. The established color has a maximum absorbance of 655 nm, The molar absorptivity was (1.012 × 104 L/ mol . cm ) for concentrations obeyed Beer’s law in the range (0.5 - 34) μg. mL ^-1. The method was of high accuracy and precision, as the recovery rate was 97.96%, the relative standard deviation rate was less than 1.5% and the correlationcoefficient more than 0.99 which indicates that the developed method is a good. The CAR product was formed in the ratio of 1:1 )CAR: leichmann dye(. The optimal conditions for the reaction were studied and the method was successfully applied to determine CAR in the pharmaceutical preparations.