Preparation, Identification and Antimicrobial Activity of Silver (I) and Copper (II) Nano complexes with New Azo-Schiff ligand Derivative from Theophylline drug

Abstract

Silver (I) and Copper (II) complexes were prepared. The New complexes were characterized using elemental analysis (C .H .N) and Infrared spectroscopy (FT-IR), ultraviolet-visible spectroscopy (UV-Vis.), and flame atomic absorption spectroscopy (FAAS) to determine the percentages of metal ions in their complexes, in addition to molar conductivity using DMSO solvent at a concentration of (1X10^-3M) and at laboratory temperature. The infrared spectroscopy results showed clear changes in the stretching bands of the factional groups in the complexes spectra compared to the ligand spectrum, which confirms the occurrence of the coordination process between the selected metal ions and the donor atoms in the ligand. While the results of the ultraviolet-visible (UV-Vis.) spectrum of the metal complex solutions in (DMSO) showed clear charge transfer absorption peaks of the (M→L) type, evidence of the occurrence of the coordination process. It was also confirmed by the results of the flame atomic absorption spectrum and the results of the precise analysis of the elements carbon, hydrogen and nitrogen, in agreement between the practical values ​​obtained and the theoretically calculated values ​​for the compounds under study.

      In addition to scanning electron microscopy (FESEM) spectroscopy of both copper (II) and silver (I) Nano complexes with the new ligand to measure the Nano size of each of them, the measurements showed that the complexes were within the Nano scale range, i.e. less than 100 nm, with the crystalline nature of each of them being diagnosed.

The results of molar conductivity using DMSO solvent showed the presence of ionic character of Ag (I)complex, which is evidence that the complex was charged and have Electrolytic character with the presence of chloride ion outside the coordination sphere, and that the tridentate ligand is neutral while the copper (II) Nano complex showed Non-electrolytic behavior. their proposed geometrical shapes, where the octahedral structure was proposed for the copper(II) Nano complexes and the tetrahedral structure Nano silver (I) complexes. Their biological activity was studied against two specific types of pathogenic bacteria, one of which is Gram-positive (G +) Staph. aurous and the other is Gram-negative Escherichia coli (G -). The sensitivity of the bacteria was studied using the Well diffusion method, using three concentrations of (100, 1000, 500) ppm in DMSO solvent under the same conditions. The Nano complexes showed high positive results compared to the drug Theophylline. The complexes under study also showed inhibitory activity against Gram-positive bacteria that was greater than their activity against Gram-negative bacteria.