Synthesis,Antifungl and Antibacterial Evaluation for new Thiazolidinone and 1,3-Diazetidine Derivatives

Abstract

This research,included prepare of some new derivatives of the thiazolidinone ,diazetidne and evaluation of their biological effectiveness.The first step includes formation of new azo compound,from diazotizing a primary aromatic amine from 2-amino-5-mercaptothiazole with sodium nitrite in HCl, followed by a reaction coupling reaction with 2-hydroxyl naphthaldehyde. The product is then reacted with (thiosemicarbazide) or (4-amino-5- fluoro-1H-pyrmidine-2-one)to form a Schiff base derivative B1 and B3, which B1 reacts with α-chloroethylacetate by[2+3] cycloadition to yield a thiazolidinone derivative and B3 reacts with (4-bromophenlisocyante) or (4-nitrophenylisothiocyante) by[2+2] cycloadition to yield diazetidine-2-on and diazetidine-2-thione . Their structures have been characterized by FT-IR, 13C-NMR, and 1H-NMR spectroscopic methods. The antibacterial activity of the prepared compounds were studied against Gram-positive bacteria (Staphylococcus aureus) and Gram-negative bacteria (Acinetobacter baumannii).Furthermore,some new derivatives were evaluated as antiofungals .against Yeast (Candida Albicans) And presenting it as a future study of the importance of heterocyclic compounds in many medical, biological, chemical and physical applications.