Preparation and characterization of new ligand derived from dithiocarbamate and their metal complexes with biological study

Abstract

The study involved creating a new dithiocarbamate derivative ligand, which is known for its significance in both medical and industrial fields. This was accomplished by joining the CS₂ group with the substituted  Schiff base 4-((1-(4-Chlorophenyl) imino) ethyl)aniline in basic medium to create the derivative sodium  (4-((1-(4- Chlorophenyl) imino) ethyl) phenyl) carbamodithioate. The derivative is then reacted with the chlorides of Cu(II), Co(II), Ni(II), Pt(II) and silver nitrate Ag(I), and to create complexes of that derivative. Melting point measurements are performed using ultraviolet spectroscopy, infrared spectroscopy, mass spectroscopy, nuclear magnetic resonance spectroscopy, and other physical properties to examine the behavior of the derivative and the complexes made from it, as well as examining their biological efficacy as anticancer agents .