The role of the rs2144908 SNP of the HNF4A Gene in T2DM of Iraqi Patients

Abstract

High blood glucose levels are a hallmark of type 2 diabetes mellitus (T2DM). A connection between genetic variations and the incidence of type 2 diabetes has been shown by several studies conducted in various nations, while others are unable to detect a noticeable outcome. In Iraq, diabetes has become an epidemic in the past ten years, paralleling the global rise in the prevalence of diabetes mellitus. The goal of our research was to examine the relationship between T2DM disease in Iraqi patients and the polymorphism of the HNF4A SNP rs2144908. A group of 100 healthy control individuals and a group of 100 T2DM patients participated in a case-control study. Using specially created primers for this research, the RT-PCR technique was utilized. The findings of the assessment of biochemical parameters showed a marked rise in the codominant, dominant, overdominant, and additive genotype models between the two groups. In codominant characteristics, it indicates that for GG, GA, and AA, insulin, HOMA-IR, TG, and VLDL have shown values, while in dominant for GG vs. GA + AA, the insulin, HOMA-IR, cholesterol, TG, LDL, and VLDL have shown significant values. As we Know this is the first study in Iraq deal with this gene with T2DM, so the study indicated that the development of T2DM is significantly influenced by HNF4A rs2144908 G/A in Iraqi patients.