Synthesis , Characterization and Biological activity of New Heterocyclic (4-(pyridin-2-yl)phenyl)-1,2,4-triazolidine-3-thione Derivatives

Abstract

     Benzoin is prepared by the condensation of two aldehyde molecules in the presence of potassium cyanide as a catalyst. The carbonyl group of the benzoin reacts with the primary amine groups of the phenylhydrazine derivative to give a hydrozone derivative (Schiff base). Sodium thiocyanide reacts with the imine group by ( 2+3 ) addition reaction in acidic media  to produce a five-ring heterocyclic derivative of  1,2,4-triazolidine-3-thione Derivative. The product have biological activity with Escherichia coli and Staphylococcus.  , The course of interaction was followed up with TLC, and the compounds prepared were diagnosed with infrared radiation spectrum FTIR and nuclear magnetic resonance spectrum ¹H-NMR.