Spectrophotometric Determination of Acyclovir Drug by Azo Coupling With 4,4'-Sulfonyldianiline and Study Properties of Thermodynamic.

Abstract

  Determination of Acyclovir (ACV) in both pure and pharmaceutical preparations is carried out using a simple, accurate, and controlled spectrophotometric method. This process is done by anticreative with 4,4'-sulfonyldianiline (SDA). Optimal conditions were determined by the following factors. In this research the detector (SDA) was used in addition to a suitable oxidizing agent with a basal solution of sodium hydroxide. Several factors affecting the course of the reaction have been identified and studied, including the reaction time and optimal temperature for the formation of a colored product (AZO) applicable to the limits of the Bear Lambert Act (2.5 to 22.5 ~ g/mL) at 620 nm wavelength. the molar absorption, Sandell's sensitivity, detection limit (DOL) and quantitative limit (LOQ) were1048.28L.mol^-1.cm^-1, 0.3204 μg.cm^-2, 0.243 μg.ml^-1 and 0.738 μg.ml^-1 respectively. The proposed method was successful for determining the pharmaceutical anti-drug (ACV) in pharmaceuticals. Dynamic functions have been identified including thermal (∆H) enthalpies, (∆S) entropic, and caps free energy (∆G) the absorption process of the drug is not automatic, the internal thermal process has made the system more regular