Exploring the Antimicrobial Activity of some Oreganometallic complexes Derived from 6- methoxy -2- amino Benzothiazole

Abstract

The Oregano Metallic complexes of Cobalt (II) and Nickel (II) were prepared by Complexation reaction with new organic compound Derived from (6- methoxy -2- amino Benzothiazole) type Schiff base (DTIMP)  . The structures of these organometallic complexes were verified by several spectroscopic techniques ;by using Carbon , Hydrogen and Nitrogen Elemental analysis technique  , FT-IR spectroscopy , UV-Vis. spectroscopy. and in order to determine the proportion of elements in their complexes, the technique of (FAAS) spectroscopy was used. a DMSO at a concentration of (1ᵡ10^-3 M) was Used as a solvent to measure the electrolytic property of complexes..

    The Comparison of the ligand spectrum (DTIMP) with the organometallic complexes in infrared technique showed a difference suitable for explaining the Complexation process ;this was also supported by the interpretations obtained from the UV-vis spectra of the ligand and its organometallic complexes, where the complexes showed high-intensity electronic transitions due to charge transfer of the type (M→L). Also, estimating the percentage of elements, confirming the correctness of their chemical composition, and studying the electrolytic properties, which showed that the complexes are non-electrolytes, supports the previous spectral interpretations. So the behavior of the didentate ligand type N,O donor atoms with mono negative charge .Their proposed geometrical shapes, where the octahedral structure was proposed .

      The antibacterial activity of the organometallic complexes under study was studied, and two types of Gram-positive and Gram-negative pathogenic bacteria were selected., Staph. aurous and Escherichia coli (G -) respectively, by using the Well diffusion method, with three concentrations of (100, 500, 1000) ppm in DMSO as solvent the sensitivity of these bacteria was studied . As a result of this study, it was shown that the metal complexes had a higher bacterial activity than the ligand, based on the inhibition zone value measured in millimeters.