Synthesis, Identification and Breast cancer Studies of New Bi-Cyclic Oxazepine and Diazepine Derivatives

Abstract

         In this study, new compounds were produced to form several new Schiff bases by combining compounds {1, 4, 5, 6, and 7} with di-carboxyl groups, and by combining compounds {2 with 3} with compounds containing an amino group. Through this condensation, six- and seven-membered rings were obtained, in addition to five-membered rings such as triazoles and oxazoles with seven membered ring like oxazepane and diazepine, which are important and fundamental compounds used in various industrial fields, such as pharmaceuticals, vitamins, dyes, and many industrial and natural products. Triazoles and their derivatives are among the important compounds used in the manufacture of nucleic acids, enzymes, and polymers. The structural formulas of these compounds were diagnosed and determined using spectroscopic studies such as infrared spectroscopy (FT-IR), carbon nuclear magnetic resonance spectroscopy (13C-NMR), and proton nuclear magnetic resonance spectroscopy (1H-NMR). Biological activity was utilized according to the functional groups of these compounds and their appearance in each spectrum. The difference was also found in the substituted groups during the comparison of the derivatives preparation process.