The Antibacterial and Anti-biofilm Efficacy of Nanoparticles Against Multi-Drug Resistant Bacteria Associated with Periodontitis Disease.

Abstract

   Periodontitis is defined as a long-lasting multifactorial inflammatory  disease include the breakdown of the tooth's supportive tissues, such as the bone, soft tissues, and periodontal ligament .its initiation and progression is related to biofilm formation, unhealthy meals characterized by high carbohydrate intake, smocking ,hormonal changes and poor oral hygiene .it is considered as the most important  leading cause  of tooth loss so it is necessary to improve the treatment of periodontitis .  the traditional management of periodontitis is local or systemic antibiotic, mouthrinse, dentifrices, along with scaling and root planning.

Nanoparticles (NPs) have been increased interest in dentistry in the last few years. Their favorable biological and physicochemical characteristics can increase periodontitis diagnosis, prevention, and therapy. NPs have demonstrated antibacterial activity against pathogens that cause periodontal disease. Additionally, nanoparticles can limit the generation of exopolysaccharides by oral cavity bacteria and prevent biofilm development.