PREPARATION OF A NEW PYRIMIDONE DERIVATIVE AND STUDY OF ITS ABILITY AS ANTIMICROBIAL AGENT AGAINST GRAM NEGATIVE AND GRAM POSITIVE BACTERIA
Abstract
In this paper a new pyrimidone derivative (5,5-diphenyl-4, 6-dioxo-3-tosylpyrimidine)(DDTP) has been prepared for 5,5-diphenyl-4, 6-dioxo-pyrimidine (DDP) by using p-toluenesulfonyl chloride and dry pyridine.
It was noted that the product has substituted tosyl group at position N-3, as indicated by physical measurements, C, H, N analysis, and UV,IR, and 1H-NMR
spectroscopy identifications. Also the work was determined the antimicrobial activity properties of the product, represented by inhibition diameters (IZ.mm), minimum inhibitory concentration(MIC), and median iethal dose (LD50).
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