Effect of Methotrexete (MTX) Treatment on Lipid Profile In Female Patients With Active Rheumatoid Arthritis
Abstract
Abstract
Rheumatoid arthritis is a chronic inflammatory disease with an axes of cardiovascular morbidity and mortality due to accelerated atherosclerosis. patients with active RA frequently show an atherogenic lipid profile, which has been linked with the inflammatory reaction. Methotrexate, a pivotal pre-inflammatory cytokine implicated in pathogenesis of atherosclerosis in RA, may be involved in the development of the altered lipid profile observed in active RA. Thirty female patients with active RA (range of age 40-67 years) and 45 apparently healthy volunteers participated in the study .Total cholesterol(TC) , high density lipoprotein cholesterol (HDL-C) low density lipoprotein cholesterol (LDL-C), triglycerides (TG), the atherogenic index ratio (cholesterol/HDL cholesterol) and the ratio(LDL-C/HDL-C) were measured at base line and after 1 year of treatment, No differences were detected in serum TC,TG , LDL-C except HDL-C in non MTX users and subjects taking MTX . In our study investigate the effects of methotrexate treatment combination with inflammatory markers on lipid profile patients with active RA.
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