Neurobehavioral Impacts of Xylazine and Piracetam Interaction on NADH Oxidase in the Rat Brain

Shaker M. Kermasha; Mohammad T. Naqi Al-Bayati

doi:10.36326/kjvs/2024/v15i217192

Authors

Shaker M. Kermasha Department of Physiology, Biochemistry & Pharmacology /Faculty of Veterinary Medicine/University of Kufa.
Mohammad T. Naqi Al-Bayati Department of Physiology, Biochemistry and Pharmacology, Faculty of Veterinary Medicine, University of Kufa, Najaf; Iraq.

DOI:

https://doi.org/10.36326/kjvs/2024/v15i217192

Keywords:

Keywords: Xylazine, Piracetam, Neurobehavior, NADH oxidase, Brain.

Abstract

In the present study, the effects of different doses of xylazine combined with piracetam were investigated through different behavioral experiments. Xylazine is alpha 2 adrenergic agonist a veterinary sedative, and analgesic agent. Piracetam is gamma-aminobutyric acid, a nootropic compound, are known to affect brain function and behavior individually.

Design: Twenty adults female Wistar albino rats were randomized divided into four equal groups: control, xylazine (5 mg/kg i.p.) group, piracetam (600 mg/kg i.p.), xylazine and piracetam combination group, motor performance was assessed by Open field. Marble Burying, Wire hanging assay tests were done for cognitive and behavioral evaluation. and biochemical parameters NADH oxidase in the brain were done by ELISA.

Results: The results of neurobehavioral tests showed significant changes in the treated three groups compared to the control group. While, NADH oxidase level in the brain if there was a significant decrease in the Xylazine group, Piracetam group, and Xylazine & Piracetam group Comparison with the control group.