Cytogenetic Effects Of Tacrolimus After Chronic Oral Administration In Male Albino Rats
DOI:
https://doi.org/10.36326/kjvs/2015/v6i23986Keywords:
Chronic toxicity, cytogenetic effect, TacrolimusAbstract
This study was carried out to investigate cytogenetic effects of chronic exposure of an immunosuppressant Tacrolimus in male albino rats. Thirty albino male rats were divided into 3 equal groups, the first one (T1) administrated orally therapeutic dose 70μg/kg.BW of Tacrolimus. The second group(T2) dosed double dose 140 μg/kg.BW of Tacrolimus, while the third group dosed distilled water with drops of ethanol as solvent like in treated groups and considered as control one(C). cytogenetic study included mitotic index, chromosomal aberration and blast index, the mitotic index showed significant decrease in both treated groups compared with the control one, the blast index showed significant decrease in T2 group compared with T1 and the control group. Chromosomal aberration in the stem cells of bone marrow represented by ring chromosome observed in T2 group which received double dose of drug. In conclusion Tacrolimus chronic exposure in rats indicate some genetic effect which needed more investigations in other species and even man.Downloads
Download data is not yet available.
Downloads
Published
2015-12-31
How to Cite
AL-Ameedi, A. I. M., AL-Rekabi, F. M. K., & Ayad, Z. M. (2015). Cytogenetic Effects Of Tacrolimus After Chronic Oral Administration In Male Albino Rats. Kufa Journal For Veterinary Medical Sciences, 6(2), 75–80. https://doi.org/10.36326/kjvs/2015/v6i23986
Issue
Section
Articles
License
Copyright (c) 2015 Ali Ibrahim Mohammed AL-Ameedi, Falah Muosa Kadhim AL-Rekabi, Zahraa Mohammed Ayad
This work is licensed under a Creative Commons Attribution 4.0 International License.