Effect of different doses of ethanolic extract of date palm pollen grains on serum gonadotropin and total Glutathione in mature female rats

Abstract

This study was focused on the effect of different doses of DPP on antioxidant status  and gonadotropin hormones of adult female Wister rats,  sixty male rats were randomized into 6 groups (A-F). Group A received distilled water (control group). while groups B-F were administration  50, 100 , 150 , 200 and 250 mg/kg of DPP extract  respectively for twenty eight (28) days.  Blood samples were drawn prior to administration (day zero) and every fourteen days for the estimation of serum FSH,LH and Glutathione concentration. 28-day daily oral administration of ethanol crude extraction of date palm pollen to female rats is associated with high circulating GSH concentration. And an elevation in serum FSH and LH concentrations in groups received 100mg/kg of DPP extract .

Conclusions: Data from this study identified that in a dose more than 100mg/kg there were no dose related effects.