Study the effect of some immunological aspects on Newzealand Rabbits drenched with different concentrations of copper sulfate and zinc

Abstract

The study aimed to evaluate the effects of watery solutions of zinc sulfate and copper sulfate on some immunoglobulins and complement, and on the total and differential Leukocyte count in 36 Newzealand rabbits which divided into 6 groups (T1, T2, T3, T4, T5, T6), 6 rabbit for each group had been drenched orally with 1 ml. contained 0.5, 5, 10 mg of zinc sulfate solution for T4, T3, T2 groups, respectively, while T5 and T6 groups drenched with 0.5 and 0.25 mg of copper sulfate solution, respectively, whereas the T1 group allowed without treatment (control).

    The results showed significant increase (P<0.05) of immunoglobulin IgM in T4 group in compare to T1, T2, T5. In addition to significant increase of IgM in T3 and T6 in compare to T2, and IgA in T2, T6 to significantly than T1 and T5. In respect to total and differenced Leukocyte count, the results revealed that the Neutrophil count did not affected by the different concentrations of copper sulfate and zinc sulfate whereas the number of Monocytes was increased in T2 in compare to other group. Also, the count of Lymphocytes was increased significantly (P<0.05) in T4 more than that in T1 and also in T5 when compared with T1, T3, T6.