Protective role of soybean lecithin in reducing hypercholesterolemia and DNA fragmentation inducing by high cholesterol in adult male rats

Abstract

The present experiment was investigated to study the ameliorative role of soybean lecithin  specially phosphatidylcholin on some lipid profiles, glycemic index and DNA damage in intact and hypercholesterolemic infected rats.Thirty two adult male rats have been used in this study, were randomly selected and equally divided in to four groups as follows C, T1 , T2, T3.They were treated orally (daily) for 42 days as follows; C:control group, were given distilled water by gavage needle, rats of this group were given soybean lecithin only (430mg\kg\day) orally; T2:rats of this groups were given only cholesterol (10gm\day) orally; T3: rats of this groups were given soybean lecithin (430mg\kg\day) orally, and high cholesterol (10gm\day) orally.The daily supplementation of soybean lecithin induces a significant decrease (p > 0.05) in total cholesterol (TC) and triglyceride (TG) in both intact and hypercholesterolemic infected rats respectively.Moreover,the glycemic index reveals a significant decrease in both glucose concentration and insulin resistance,