Serum calcium level and some physiological markers during Pre-eclampsia and normal pregnancy in Babylon province women

Abstract

Background: preeclampsia (PE)is a pregnancy – related hypertensive disorder occurring in the second half of the pregnancy. The calcium mineral has been proposed to play important role in the pathogenesis of preeclampsia.

Subjects and methods: The data was collected from 50 normal pregnant women,35 mild preeclamptic women and 30 severe preeclamptic women who were admitted in the Babylon maternity and pediatric teaching hospital between February 2012 and December 2012.The blood samples were collected and analyzed for serum total calcium, serum ionized calcium, serum albumin, The data on body mass index (BMI),a maternal and gestational ages, blood pressure (BP) values were collected and the data were analyzed using analysis of variances (ANOVA).

Results: The (BMI) and (BP) values  in the preeclamptic women were significantly higher than those of individuals with normal pregnancy(p<0.001),the serum total calcium(Ca) and serum albumin(Alb) levels were highly significant lower in hypertensive pregnant in comparison with healthy ones(p<0.001),while ionized calcium levels had no significant difference between mild preeclamptic women(p>0.05) as comparison with normal pregnancy, but were significant lower(p<0.05) in the severe preeclamptic women as compared with control and mild preeclamptic groups.

Conclusion: single estimation of total and ionized calcium, and serum albumin levels late in the second and third trimesters of pregnancy have a little value in the prediction of preeclampsia when the disease process was usually manifest, our study is recommended to properly performed not just these biochemical markers, additionally we must investigated the related vitamins that may be contribute in this disorder, and these tests must be early analyzed in pregnancy for prediction of the subsequent development of preeclampsia.