Histological and Physiological Effect of Chitocal On Liver, Some Parameters of Blood And Body Weight In The Male Albino Rats

Abstract

This study was carried out to investigate the effect of the oral administration of chitocal on liver, some parameters of blood and body weight in the male albino rats.

For this purpose sixteen males mature albino rats which were divided into two equal groups, control group (G₁) administrated normal physiological saline (0.9% NaCl) and second group (G₂) administrated orally for 35 days (5 weeks), with 25mg/ kg/ b.w/ day of chitocal. liver and sample of blood was taken from the male rats for the current study. The exposure of rats to chitocal caused histopathological changes in the liver of the male rats were revealed variety to the lesions like accumulation of mononuclear cells (inflammatory cells) around central vein.

     The rats exposed to chitocal showed massive necrosis in hepatocyte and hydropic degeneration with loss of architecture of liver tissue, significant  decrease (P<0.05) in some Parameter of blood such as (PCV, WBC, Hb) and significant increase (P<0.05) in enzyme activity level of GPT (Glutamic pyruvic transaminase), GOT (Glutamic oxaloacetic transaminase) and ALP (Alkaline phosphatase). Also it was showed a significant P<0.05 decrease in body weight (B.W).