Synthesis , Characterization and Biological Activity of Some New Heterocyclic Compounds Containing Azo group

Abstract

This study  includes  preparing the new Azo compound (D_H) Dissolved of 1,4- phenylenediamine in a mixture of Sodium nitrite ,concentrated hydrochloric acid and  4-hydroxyacetophenone then preparing the Schiff  base (D) By reacting the prepared Azo with 2-aminoanthraquinone in the presence of drops from Glacial acetic acid ,via microwave method , the Synthesis of Imidazolidine derivatives (D₁-D₂) by reacting (D) with the amino acids Lucien and Tyrosine respectively, then react (D) with Maleic Anhydride and Phthalic Anhydride to Prepare the seven membered rings of Oxazepane (D₃) and Benzoxazepene (D₄) , respectively  . The (TLC) technique was used to follow the reaction , iodine was used as a moderator, and after purification of the prepared derivatives  the melting Points were measured.  The infrared (FT-IR) spectra  and The spectra of Proton NMR (¹H NMR) .