Synthesis and Characterisation of New Hexahydropyrimidine Derivatives, and Study of Their Effect as Anti-parasite.
Keywords:
Pyrimidine derivatives, hexahydropyrimidine, echinococcosis granulosusAbstract
New pyrimidine derivatives (hexahydropyrimidine), 4-(2,4-dichlorophenyl)-6-phenyl-1,3-hexahydropyrimidine-2-amine (NH), and 6-(3-aminophenyl)-4-(2,4-dichlorophenyl)-1,3-hexahydropyrimidine-2-amine (Nm-NH2) were synthesised and identified with FT-IR, Mass and H1-NMR spectra. The new hexahydropyrimidine (NH, Nm-NH2) applied to the parasite echinococcosis granulosus gave a different result. The prepared compounds' inhibition ratio was NH (78.9%) and Nm-NH2 (66.6%).
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