Obesity-Related Type 2 Diabetes Mellitus and HHEX Gene rs1111875 C/T Polymorphisms in Iraqi Population.

Abstract

type 2 diabetes mellitus(T2DM) is a complex metabolic disease. Diabetes mellitus has quadrupled globally in the last three decades. Many studies have shown how genetic diversity contributes to the development and progression of T2DM. The hematopoietic expressed homeobox (HHEX) gene is hypothesized to be linked to the risk of T2DM. The aim of this study was to look at the association of the HHEX gene polymorphism (rs1111875 C/T) with T2DM in the Iraqi population and see if obese individuals were affected more than other patients. Methods: 100 T2DM obese and 100 controls obese. The RFLP -PCR assay Technique was used to genotype HHEX rs1111875 C/T, making use of newly-designed primers. Results: The study's parameters demonstrate no significant difference between T2DM obese and obese control groups. The study concluded that there is no significant difference in genotypes Codominant, Dominant, Recessive, and Additive genotype between groups for HHEX rs1111875 C/T. and Chol, TG, and VLDL were significant between CC and CT, age was borderline. There is a negative relationship between (BMI and CHO and TG) and (insulin and HOMA-IR and LDL, VLDL). In conclusion, according to the findings of this study, the rs1111875 C/T polymorphism in the HHEX gene revealed no significant difference in genotypes in any of the codominant, dominant, recessive, or additive models.