Synthesis, Biological Activity, and Molecular Docking Studied of New Substituted Hydrazones
DOI:
https://doi.org/10.36329/jkcm/2022/v2.i9.13323Keywords:
hydrazones, antibacterial, antifungal, molecular dockingAbstract
Series of new hydrazones derived from different carboxylic acid hydrazides and aromatic aldehydes (7-10, 20-25) have been synthesized and characterized by spectral techniques (FT-IR, 1H NMR, 13C NMR, and Mass spectrometry). The target compounds are designed to have the different substituents at the para position for both parts of the structures (hydrazide and aldehyde parts. The synthesized compounds have been evaluated as antimicrobial agents by studying their biological activity against two bacteria strains Staphylococcus aureus and Staphylococcus epidermidis (as gram-positive bacteria), Escherichia coli and Klebsiella sp (as gram-negative bacteria), the antifungal activity was studied against Candida albicans fungi. The obtained results showed a moderate antimicrobial activity for the test compounds when compared with ampicillin. The synthesized compounds were also subjected to molecular docking studies which were carried out against the bacteria strain Staphylococcus aureus DHFR.
Downloads
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2023 Journal of Kufa for Chemical Sciences
This work is licensed under a Creative Commons Attribution 4.0 International License.
Open-access Statement
The journal « Journal Of Kufa For Chemical Sciences» provides immediate open access to its content on the principle that making research freely available to the public supports a greater global exchange of knowledge. Full-text access to scientific articles of the journal is presented on the official website in the Archives section.
This is in accordance with the BOAI definition of open access. The licensing policy is compatible with the overwhelming majority of open access and archiving policies.
The journal «Journal Of Kufa For Chemical Sciences» is an open access journal, which means all its content is freely available without charge to the user or his/her institution. Users are allowed to read, download, copy, distribute, print, search, or link to the full texts of the articles, or use them for any other lawful purpose, without asking prior permission from the publisher or the author as long as they cite the source.The journal is licensed by Creative Commons Attribution International( CC Attribution 4.0) .