Synthesis , Identification and Study The Biological Activity of Some Tetrazole Derivatives From Imidazole Derivative

Authors

  • Zainab fadhil
  • Shaimaa Adnan

Abstract

     This research involved synthesis of  tetrazol derivatives by a chain of reaction. The first step includes react between o-phenylenediamin with 5-amino salicylic acid to get 4-amino-2(1H-benzo[d]imidazol-2-yl)phenol(1).(1) react with (4-dimethylamino benzaldehyde ,4-hydroxy acetophenone ,Vanillin, Acetylacetone , 4-Bromoacetophenone and m-aminoacetophenone) to get schiff base derivatives (2,3,4,5,6 and 7) consecutive.(7) react with (4-chlorobenzaldehyde ,4-Bromoacetophenone) to get schiff base derivatives (8,9) consecutive.(1) react with salicylaldehyde and sodium Nitrate in acid medium to get azo derivative (18).All schiff base derivatives (2,3,4,5,6,7,8,9) react with sodium azide to get tetrazol derivatives (10,11,12,13,14,15,16 and17) consecutivly.(18) which react with ( 3-nitro aniline , 4- amino acetophenone , 2-amino-5-nitrothiazole ,2-aminobenzimidazole ,2-aminopyridine and benzidine) to get schiff base derivatives (19,20,21,22,23 and 24) consecutive,which react with sodium azide to get tetrazole derivatives (25,26,27,28,29 and 30) consecutive.All these compounds characterized by means of  FT-IR,and some of the compounds by means of 1H-NMR, and13C-NMR and follow the reaction by Rf-TLC and measurement of melting point.

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Published

2018-04-30

How to Cite

fadhil, Z., & Adnan, S. (2018). Synthesis , Identification and Study The Biological Activity of Some Tetrazole Derivatives From Imidazole Derivative. Journal of Kufa for Chemical Sciences, 2(2). Retrieved from https://journal.uokufa.edu.iq/index.php/jkcs/article/view/3372