Synthesis , Identification and Study The Biological Activity of Some Tetrazole Derivatives From Imidazole Derivative
Â Â Â Â This research involved synthesis ofÂ tetrazol derivatives by a chain of reaction. The first step includes react between o-phenylenediamin with 5-amino salicylic acid to get 4-amino-2(1H-benzo[d]imidazol-2-yl)phenol(1).(1) react with (4-dimethylamino benzaldehyde ,4-hydroxy acetophenone ,Vanillin, Acetylacetone , 4-Bromoacetophenone and m-aminoacetophenone) to get schiff base derivatives (2,3,4,5,6 and 7) consecutive.(7) react with (4-chlorobenzaldehyde ,4-Bromoacetophenone) to get schiff base derivatives (8,9) consecutive.(1) react with salicylaldehyde and sodium Nitrate in acid medium to get azo derivative (18).All schiff base derivatives (2,3,4,5,6,7,8,9) react with sodium azide to get tetrazol derivatives (10,11,12,13,14,15,16 and17) consecutivly.(18) which react with ( 3-nitro aniline , 4- amino acetophenone , 2-amino-5-nitrothiazole ,2-aminobenzimidazole ,2-aminopyridine and benzidine) to get schiff base derivatives (19,20,21,22,23 and 24) consecutive,which react with sodium azide to get tetrazole derivatives (25,26,27,28,29 and 30) consecutive.All these compounds characterized by means ofÂ FT-IR,and some of the compounds by means of 1H-NMR, and13C-NMR and follow the reaction by Rf-TLC and measurement of melting point.
How to Cite
Copyright (c) 2018 Ù…Ø¬Ù„Ø© Ø§Ù„ÙƒÙˆÙØ© Ù„Ù„ÙƒÙŠÙ…ÙŠØ§Ø¡ | Kufa Journal for Chemistry
This work is licensed under a Creative Commons Attribution 4.0 International License.
The journal « Journal Of Kufa For Chemical Sciences» provides immediate open access to its content on the principle that making research freely available to the public supports a greater global exchange of knowledge. Full-text access to scientific articles of the journal is presented on the official website in the Archives section.
This is in accordance with the BOAI definition of open access. The licensing policy is compatible with the overwhelming majority of open access and archiving policies.
The journal «Journal Of Kufa For Chemical Sciences» is an open access journal, which means all its content is freely available without charge to the user or his/her institution. Users are allowed to read, download, copy, distribute, print, search, or link to the full texts of the articles, or use them for any other lawful purpose, without asking prior permission from the publisher or the author as long as they cite the source.The journal is licensed by Creative Commons Attribution International( CC Attribution 4.0) .