Preparation. Identification and Antioxidant of some new Imidazolidine tetrazole, and thiazolidine derivatives from Schiff bases

Abstract

Several heterocyclic derivatives were developed for this study.. The synthetic strategy was carried out in two stages: first, the preparation of three different types of derivatives of Schiff bases (F1-F3); It was prepared by reacting one mole of p-phenylenediamine with two moles of aromatic aldehydes (4-nitrobenzaldehyde, 4-(methylthio) benzaldehyde, 4-(pyridin-2-yl) benzaldehyde) as a first step to prepare Schiff bases (F1). -F3). The second step was the formation of pent acyclic heterocyclic compounds (imidazolidine, tetrazole, and thiazolidine) by reacting Schiff bases with different amino acids, sodium azide and thioglycolic acid. This is done by taking two moles of it to form five-ring heterocyclic derivatives (F4- F19). The progress of the reactions was monitored using TLC technology. The compounds were characterized and characterized using" FT-IR, H-NMR, and 13C-NMR spectra". The biological activity of some of the compounds used was also taken from bacteria Such as (Escherichia coli and Staphylococcus aureus), as well as their high efficacy of these compounds against these bacteria was proven (F1, F2, F8, F4, F10). Antioxidant compounds were also studied, and then molecular docking investigations were performed using MOE software. Good binding interactions have been reported when using heterocyclic compounds (F10) as targets,