Synthesis , Characterization of New Poly Dentate Schiff Base ligand With Cu(II) ,Ag(I),Cd(II) ,and Pd(II) Complexes And Studying Their Biological Activity As Antioxidants And Anticancer

Abstract

The Schiff base ligand was prepared by reacting Diacetyl monoxime with O-phenylene di-amine. Then react the resulting compound from the first step with 4-aminoantipyrine to produce the ligand [(2E,3E)-3-(((Z)-4-amino-1,5-dimethyi-2-phenyl-1,2-dihydro-3h-pyrazol-3-ylidene)amino)phenyl) imino) butan-2-one oxime].Then the step of preparing the complexes is by reacting with chlorides of the elements CuCl₂.2H₂O, CdCl₂.2H₂O,PdCl₂and AgNO₃. The complexes exhibited a metal ion-to-ligand ratio (M:L) of 1:1. The Cu(II) complex displayed an octahedral geometric shape, while the Ag(I) and Cd(II) complexes displayed tetrahedral geometric shapes. On the other hand, the Pd(II) complex displayed a square planar geometric shape. The structure of the compounds was confirmed through a series of spectroscopic measurements, including FTIR, ¹H-NMR, ¹³C-NMR, UV-Vis, (C, H, N, S), FESEM, magnetic susceptibility, molar conductivity, and melting point. Assessing the biological efficacy of ligands and Ag(I) through antioxidant testing and anticancer testing is a multifaceted process and complex. It was found that it has good effectiveness against HL-60 leukemia and MCF-7 breast cancer cells, and it can be used as a medicine after being well studied.