The Assessment of Serum Cytokeratin 18 and Liver Function Tests in Chronic hepatitis B patients.

Abstract

Background

     Chronic hepatitis is a clinical and pathological disorder, some biochemical testes like serum Alanine Amino-transferase (ALT), Aspartate Amino-transferase (AST) and total serum bilirubin (TSB) used to monitoring hepatitis diseases. Albumin  levels in serum  fall with liver disease progression, representing decreased synthesis. Prothrombin time evaluate the level of converted prothrombin to thrombin and this represent the synthetic function of the liver. In acute on chronic liver

Disease non apoptotic pattern of cell death is predominant .It is confirmed by cleaved K18. Cytokeratin 18 was measured  by  ELISA

Objectives: This study aimed to measure the ALT ,AST  ,TSB, Albumin ,PT and K18 levels inthe serum of Iraqi patients  who were having Liver disease And study the correlation  between the variables mentioned above

Materials and Methods: The study included approximately One hundred subjects, ages 20 to 60 year, who were split into two groups , Fifty patient with chronic hepatitisB virus,The second group comprises of 50 subjects who look to be in good health and serves as the control group.

Results  

    Serum levels of ALT, AST, TSB, PT and albumin displayed a significant increase in chronic hepatitis B virus group compare with control group .

Also, the current study revealed non-significant association of liver function tests with different age groups, except total serum Bilirubin values decline significantly with increasing age, and there was a significant gender difference in AST concentration. While, there was non-significant gender difference in further liver parameters.

Conclusion

Among chronic hepatitis B patientin Babylon province, abnormality of liver function tests in different age and gender groups; indicat the significant linke with the development of  chronic hepatitis B virus.