Preparation, Characterization, and Antibacterial Evaluation of New Derivatives of Nicotinic and Mefenamic Acids

Abstract

A new series of heterocyclic derivatives of nicotinic and mefenamic acids was obtained by reacting the hydrazine of nicotinic and mefenamic acids with p-nitrophenyl isocyanate, O-mercaptobenzoic acid. The derivatives hydrazone was obtained by reacting a new azo compound containing a free acytal group with nicotinic and mefenamic acids hydrazide and the reaction was monitored by TLC technique. The chemical structures of the intermediate and the final compounds were characterized by measuring melting points, 13C-NMR, 1H-NMR, and FT-IR. Antibacterial studies of some of the compounds were performed. The impact of the biological activity of these compounds was examined against two bacteria types, (Staphylococcus aureus) and (Acinetobacter baumannii).