Synthesis, Identification and Study of Anti-Tumor Activity for Macrocyclic Formazan-Triazan Compounds

Abstract

Formazan derivatives composites were equipped concluded condensation reactions and using altered solvents and mediums. They were derived from Mefenamic acid and were converted to a primary amine by reacting it with semicarbazide and going through an esterification step, where this amine was converted to Anil derivative for coupling reaction. Preparation of Macro-Cyclic-Formazan and Macro-Cyclic-Formazan-Triazan, which was synthesized for the first time as a bioorganic compounds via cyclization step with coupling reaction. The physical and chemical properties of the synthesized compounds are provided. The compounds were identified by FTIR, ¹H.NMR and ¹³C.NMR spectroscopy, and evidence of the formation of these compounds was obtained. The second part of the research included a study of its behaviour against breast cancer as a type of cancer, where the results showed the emergence of strong inhibition of tumour cells at a concentration of (600 ppm) for Macro-Cyclic-Formazan-Triazan indicating the effect of heteroatoms on the effectiveness of the compound.