Synthesis,Characterization biological activity and molecular docking of triazole derivatives from the medication sulphadoxin

Abstract

                          In this study, click chemistry is used to synthesize heterocyclic derivatives from the medication sulphadoxine.  To create the (S) derivative, sulphadoxine initially interacted with sodium nitrate, sodium hydrochloric acid, and sodium azide (1).,then P-hydroxy benzaldehyde and 3-bromo-1-propyne reacted in the second stage to form the (A) derivative, which then reacted with various aromatic ketones to create many additional chalcons derivatives (A₃-A₅). These chalcons then reacted with the (S) derivative to create the triazole derivatives (E₃-E₅).  These structures were found using TLC, FT-IR,¹H-NMR,¹³C-NMR and the study of Molecular docking of some derivatives