PREPARATION AND CHARACTERIZATION OF (OXAZAPENE AND IMIDAZOLODIN-4-ONE) DERIVATEVES WITH THIAZOLE MOIETY
The research includes preparation of new heterocyclic derivatives such (oxazepine and imidazolodine-2-one),starting from 2-amino thiazole. This work is divided in two parts:
Part one: include three steps: The first step includes the synthesis of Schiff base derivatives from the reaction (2-amino thiazole) with 4-amino benzaldehyde ,while the second step include the reaction of Schiff base with isatine toÂ form new Schiff base ,the third step includes reaction of maleic and phthaleic anhydride and tyrosine amino acid with the prepared Schiff base to form various five and seven heterocyclic rings.
Part two include two steps:
The first step includes the synthesis of Schiff base derivatives by the reaction of (2-amino thiazol) with acetyl acetone, then the reaction involves prepared of Schiff base with maleic and phthaleic anhydride to form seven membered Â ring ; All these compounds were characterized by ( FT-IR)and (C.H.N) and some of them by (1H-NMR).
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