Synthesis,Characterization of Some Metal Complexes with bis[O,O-2,3;O,O-5,6-(thiol(carboxylic)methylidene)]-L-Ascorbic Acidand Studies their Biological Activity

Abstract

The reaction of bis[O,O-2,3;O,O-5,6-(chloro(carboxylic)methylidene)]-L-ascorbic acid with the excess
of Sodium sulfide gave new product bis[O,O-2,3;O,O-5,6-(Thiol(carboxylic)methylidene)]-L-ascorbic
acid(LS), which was isolated and characterized by 1H,13C-NMR, elemental analysis (C.H.N.S), mass
spectroscopy, UV-visible and Fourier Transform infrared (FTIR) methods. The complexes of the ligand
(LS) with metal ions, M2+= (Cu, Co, Ni, Cd, Hg) and Cr3+ were synthesized and characterized by FTIR,
UV-Visible, molar conductance, atomic absorption, magnetic susceptibility, elemental analysis (C.H.N.S)
methods. The analysis showed that the ligand (LS) is coordinating with metal ions through the
tetradentate carboxylato and thiol groups manner resulting in six-coordinated metal ion in an octahedral
geometry. The TLC for (LS) and complexes showed one spot for each indicating the purity of these
compounds.
The study of biological activity of the ligand (LS) and (Co2+, Cu2+, Cd2+) complexes showed various
activities toward two types of pathogenic bacteria are Staphylococcus aureus and Escherichia coli.
Key words: Synthesis; Bis[O,O-2,3;O,O-5,6-(thiol(carboxylic)methylidene)]-L-ascorbic acid; metal Complexes;
biological activity