Preparation and Evaluation of Curcuma Longa Loaded Chitosangelatin Composite Films for Wound Healing Activity

Abstract

Chitosan and gelatin have proven wound healing properties individually. As both have Natural polymers are used as lead compounds for design of drugs in treatment of different ailments. wound healing property, the combination of these two polymers and incorporation of drugs into the composite films may show improvement in wound healing activity. The composite films were prepared with increase in gelatin concentration while curcuma longa  loaded films were prepared with increased concentrations of curcuma longa  in optimized composite film. These films were evaluated for thickness, folding endurance, water absorption capacity, antibacterial activity, tensile strength, in vitro drug release by diffusion studies and in vivo wound healing studies. The curcuma longa  loaded films shown significant difference in folding endurance, water absorption capacity, antibacterial activity when compared to blank composite film. There was no significant difference in thickness and tensile strength of drug loaded films when compared to blank composite films. Percentage of wound contraction was more for wounds treated with curcuma longa  loaded composite film than blank composite film. With the above results, it was concluded that curcuma longa  loaded chitosan-gelatin composite films had shown more wound healing property than chitosan-gelatin blank composite film and blank chitosan film without interfering in strength of film.