Synthesis of a New Series of Ethyl Indolepropionates and Study of Their Biological Activity of Some Prepared Compounds
Ethyl indolepropionate derivatives were prepared by the decarboxylative ethanolysis of indole meldrum's acid derivatives in presence of copper powder, indole meldrum's acid derivatives were prepared earlier via Yonemitsu condensation. Their structures were identified on the basis of elemental analysis, IR, NMR and melting point. Also some of the prepared compounds have been tested for their antibacterial activity against pseudomonas aerogenosa (Gram positive) bacteria by using of agar well diffusion method. Finally we found that the compounds show different activity of inhibition of growth of the bacteria.
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