Synthesis and characterization of Some Mannose Esters at C1 as a Prodrugs
Abstract
In this study, new derivatives of D-Mannose have been synthesized . These derivatives are esters of D-Mannose at anomeric center .Treatment of free sugar containing hydroxyl groups such as D-Mannose with acetone using sulfuric acid (Conc.)as catalyst lead to the formation of two five membered acetal rings ; 2,3:5,6-O-diisopropyldine-D-mannofuranose.
Treatment of α-(4-isobutyl)phenyl methyl ethanoic acid,decadecanoic acid and cis-9-octadecenoic acid with thionyl chloride give their carboxylic acid chlorides.
Reaction of carboxylic acid chlorides with 2,3:5,6-O-diisopropyldine-D-mannose give Mannose esters.
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Copyright (c) 2022 Magid J. Mohammed, Abdul-Jabbar A. Mukhlus, Wafa F. Al-Tai
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