Synthesis and characterization of Some Mannose Esters at C1 as a Prodrugs
Abstract
In this study, new derivatives of D-Mannose have been synthesized . These derivatives are esters of D-Mannose at anomeric center .Treatment of free sugar containing hydroxyl groups such as D-Mannose with acetone using sulfuric acid (Conc.)as catalyst lead to the formation of two five membered acetal rings ; 2,3:5,6-O-diisopropyldine-D-mannofuranose.
Treatment of α-(4-isobutyl)phenyl methyl ethanoic acid,decadecanoic acid and cis-9-octadecenoic acid with thionyl chloride give their carboxylic acid chlorides.
Reaction of carboxylic acid chlorides with 2,3:5,6-O-diisopropyldine-D-mannose give Mannose esters.
Downloads
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2022 Chemical
This work is licensed under a Creative Commons Attribution 4.0 International License.
Open-access Statement
The journal « Journal Of Kufa For Chemical Sciences» provides immediate open access to its content on the principle that making research freely available to the public supports a greater global exchange of knowledge. Full-text access to scientific articles of the journal is presented on the official website in the Archives section.
This is in accordance with the BOAI definition of open access. The licensing policy is compatible with the overwhelming majority of open access and archiving policies.
The journal «Journal Of Kufa For Chemical Sciences» is an open access journal, which means all its content is freely available without charge to the user or his/her institution. Users are allowed to read, download, copy, distribute, print, search, or link to the full texts of the articles, or use them for any other lawful purpose, without asking prior permission from the publisher or the author as long as they cite the source.The journal is licensed by Creative Commons Attribution International( CC Attribution 4.0) .
