Measurement Serum Levels of IFNY, IL-17 and IL-4 of Psoriasis patients in Al- Najaf City
DOI:
https://doi.org/10.36321/kjns.vi20133.2514Keywords:
Psoriasis, cytokines , Disease severityAbstract
Background: Psoriasis is an inflammatory skin disorder characterized by activation of lymphocytes, systemic and local over expression of pro-inflammatory cytokines.
Objectives: The study was designed to investigate the level of cytokines in patients with psoriasis and study the correlation of the cytokines with disease severity.
Methodology: Blood samples were collected of seventy patients with psoriasis for measurement of (IFNγ, IL-17 and IL-4) by ELISA technique.
Results: High levels of IFNγ and IL-17 were observed in patients with psoriasis. It was found that the mean levels of IFNγ and IL-17 were significantly correlated to disease severity. Moreover, the mean level of IL-4 in psoriatic patient was found to decrease significantly according to graded severity of the disease. Statistical analysis was done by using SPSS (statistical package for social sciences) in which T-test and ANOVA test were used and chi- square (X2) test for categorical data.
Conclusion: The study concluded that the level of IFNγ and IL-17 may play a key role as an indicator in the immunopathogenesis of psoriasis and markers of disease activity.
Recommendation: Using another cytokines and study effect of these cytokines with disease severity.
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Copyright (c) 2014 Muhsin A. Al- Dhalimi Ali M. Almuhana Ebtihal Ch. Abbas
This work is licensed under a Creative Commons Attribution 4.0 International License.