Effect of Metronidazole on Local Rabbit (Oryctolagus cuniculus) Spleen Over One toTwo Months

Abstract

The rabbit spleen is located adjacent to the greater curvature of the stomach on the left side of
the abdominal cavity, appearing as a tongue-like, elongated organ. This study investigated the effects
of Metronidazole at a dose of 500 mg/kg administered over one to two months. Histopathological
analysis revealed that low to moderate doses induced hyperemia and congestion in the splenic venous
sinuses, along with proliferation of white pulp and increased lymphocyte cellularity. In contrast, high
doses caused necrotic changes in both red and white pulps, with necrotic foci evident in histological
sections.