Some Toxic Effects of Potassium Dichromate on Liver and kidney cortex of adult male rabbits

Abstract

Twenty four mature adult male rabbits were divided into three groups, each group was involved eight rabbits. The experiment period was reached to six weeks. Administration route of potassium dichromate was orally via drinking water. The first group represented control group. The second treated group was administrated 50mg/kg.Bw. Of potassium dichromate, while the second treated group was administrated 60mg/kg.Bw. Of potassium dichromate. (The present work symptoms on treated groups were appeared as depression), loss of appetite, followed by hyper salivation, lacrimation and diarrhea. The liver tubules of first treated group showed fatty degeneration and intracytoplasmic vacuolization of hepatocyte, while the kidney cortex was revealed glomerulonephritis in some glomeruli, interstitial connective tissue oedema, and degeneration and necrosis in the epithelial lining of proximal and distal convoluted tubules in the first and second treated groups. On the other hand, the liver lobules of rabbit was belonged to second treated group revealed polymorphic nuclear leukocytic infiltration which surrounded the central vein, as well as sever fatty degeneration in the hepatocytes due to effect of potassium dichromate at dose 60ml/kg.B.w, this dose led to sever congestion in the branches of renal vessels in the kidney cortex of rabbits.