Impact of Cypermethrin on Some Biochemical Parameters in Rat

Abstract

Forty adult albino rats were used in this research. They were randomly divided into four groups. The first group served as control group. The other groups were subdivided into three groups according to the concentration of cypermethrin. Three concentrations of cypermethrin were applied (7.5, 15 and 30 mg/kg body weight). All treated doses were given orally every two days and the doses were continued for 30 days. This work included study the changes in the levels of some serum biochemical indices for liver and kidney functions.The findings of this study showed that cypermethrin induced a significant decrease (P<0.05) in blood total protein, albumin and globulin,  and a significant increase (P<0.05) in the concentrations of aspartate transaminase, alanine transaminase, alkaline phosphatase, in addition to urea and creatinine. The current study suggests that cypermethrin has a potential toxicity in rats as a model for mammals. Also, the negative changesthat observed in biochemical values were gradually increased with increasing concentrations of cypermethrin used in this study.