Expression Of Cyclooxygenase-2 And Interlukin-6 Mrnas In Iraqi Patients With Breast Cancer
DOI:
https://doi.org/10.36330/kmj.v19i2.13259Keywords:
Breast cancer, Cyclooxygenase-2, Interleukin 6Abstract
Background: Breast cancer is one of the most common malignant tumors that endanger women's health internationally, relatively uncommon in men, accounting for only 1% of all cancer cases. Location, way of life, age at marriage, and obesity are a few environmental variables that increase the risk of breast cancer.
Aim of study: the study aims to explain how the pro-inflammatory cytokines (IL-6) induce the inflammatory events in patients with breast cancer and to describe whether cyclooxygenase-2 promotes tumor growth in breast cancer or not.
Materials and methods: The current case-control cross-sectional study included 45 patients with a history of breast cancer, and it was done in multiple places in Hilla, Babylon Province, between November 2022 and March 2023.Interlukin-6 and Cyclooxygenase-2 by QPCR.
Results: The results have shown a significant increase of IL-6 (P < 0.05) in patients compared with control. Also, the results have shown a significant increase (P < 0.05) of COX2 in patients compared with control.
Conclusion: There is a significant increase in the means of Interlukin-6 and Cyclooxygenase-2 in the patients with breast cancer.
Downloads
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2023 marwa hussien
This work is licensed under a Creative Commons Attribution 4.0 International License.
which allows users to copy, create extracts, abstracts, and new works from the Article, alter and revise the Article, and make commercial use of the Article (including reuse and/or resale of the Article by commercial entities), provided the user gives appropriate credit (with a link to the formal publication through the relevant DOI), provides a link to the license, indicates if changes were made and the licensor is not represented as endorsing the use made of the work. The authors hold the copyright for their published work on the KMJ website, given that KMJ is responsible to appreciate citation for their work, which is released under CC-BY-4.0 enabling the unrestricted use, distribution, and reproduction of an article in any medium, provided that the original work is properly cited.
