Association Of IL-6, And IL-10 Gene Snps In Childhood Febrile Seizure

Abstract

Background: Febrile seizure are typically defined as convulsions=that-occur in children, between/6 months to 5years, who have a fever of more,,than”38 degrees Celsius, that is not associated with an intracranial’ reason such as an infection, ,head .injury, or epilepsy. It is also known as the immature brain's response to fever, which is age-dependent. As a child’s brain develops, there is an increase in neuronal excitability which puts the child at the risk of febrile seizures.

Aims: the aim of the present study is to find out the association of Inflammatory cytokines (IL-6, IL-10) SNP with the onset of childhood febrile seizure. Method- Blood samples from patients with childhood febrile seizure will be collected in a sterile condition, and the association of SNP for both IL-6 (-597) G/A, and IL-10 (-819) C/T with disease susceptibility will be studied by using allele specific PCR. Results: The case-control study of 40 patients with Febrile seizure and 40 control without Febrile seizure has revealed that a substantial difference in the frequency distribution of IL-6 genotypes between the patient group and the control group where (p =0.041). Besides, there was no discernible variation in the frequency distribution of IL-10 genotypes and alleles. (p > 0.05); therefore, none of genotypes or alleles can be regarded as risk factor or protective factor. Conclusion: The present study has concluded that IL-6(-597) G/A, (rs:1800797) single nucleotide polymorphism (SNP) was associated with Febrile seizure susceptibility, and GG, genotype considered as, risk factor, while genotype GA act as protective factor. However, it refers that the IL-10-819C/T (rs:1800871), genes may not represent the  Febrile-seizure-associated genetic risk factor.