IL-35 and IL-10 Role in The Immune Response of Colorectal Cancer in Iraqi Patients

Abstract

Background: Colorectal cancer (CRC) is presented in the colon and rectum (large intestine) and the disease is expanding worldwide, CRC ranks as the third most common cancer worldwide and cervical cancer is the fourth most common locally. It is strongly linked to bad lifestyle factors. The study of the immunosuppressive status of CRC patients through screening and laboratory tests is crucial and is one of the priorities now. The objective of this study is to assess the immune response to colorectal cancer by measuring the serum concentrations of IL-35 and IL-10.  Methods: The study has been approved by the College of Medical Al-Iraqia University. 100 male and female patients from the medical city and Al-kadhimiya hospitals suffering from problems in the colon and rectum participated in this study, they donated 5 ml of their blood which lasted for five months (from Aug. 2023 until Jun. 2024). The participants were divided into 2 groups: the 1^st one contained CRC patients, while the 2^nd contained Colorectal problems other than CRC.ELISA tests for IL-35 and IL-10 serum level estimation were used. Demographic data such as age, gender, address, and medical history were collected from the study participants. Results: The serum levels of IL-35 and IL-10 in CRC patients showed significant differences (P<0.05) when compared with the control group. Conclusion: IL-35 and IL-10 significantly appeared as indicators for the immune suppressive status of CRC patients.