A Predictive Value of Red Blood Cell Distribution Width in Hodgkin Lymphoma in Iraqi Patients

Abstract

Aim: to assess role of Red Blood cell Distribution Width as predictive factor in Hodgkin lymphoma. Patient, material, methods: the study to assess Iraqi patient including male and female with Hodgkin lymphoma age between (16-55 years) by compare RDW level at time of diagnosis then after 2 cycle and lastly at the end of chemotherapy. We enrolled in this study for period from Dec.2021 to Dec.2022 in Baghdad medical city. All patient included was send for full laboratory evaluation before beginning and during follow up. Result: The mean age of the patients was 30.49±11.24 years (range 16-55 years). Males were more common than females (56% vs. 44%).  The most common disease stage was IIB stage accounting for 42%, followed by IVB stage (36%) and IIIB stage (24%). B-symptoms present in 82% of the patients, while bulky disease (>10cm) was reported in 18% of them .The mean RDW-SD in patients with complete response at diagnosis and after two cycles therapy was 48.02±9.66 fl and 51.17±9.8 fl, respectively which was much higher than that of patients with progressive disease/partial response (28.83±10.23 fl and 43.03±11.37 fl, respectively) with significant differences. Furthermore, patients with complete response demonstrated higher mean value of RDW-CV and RDW-SD at the end of treatment (17.66±3.5% and 52.0±6.6 fl, respectively) than those with progressive disease/partial response (14.67±2.45% and 36.87±12.71 fl), with highly significant differences. Conclusion: High RDW CV and SD showed no significant association with high disease activity. Higher RDW showed significant association with anemia and low albumin. patients with complete response demonstrated higher mean value of RDW-CV and RDW-SD at the end of treatment than those with progressive disease/partial response with highly significant differences. RDW showed no significant correlation of these parameters neither with age nor with the disease stage.