Coating Orthodontic Miniscrew with Chlorhexidine Hexametaphosphate Nanoparticle (An in vitro-study)
Keywords:orthodontic miniscrew, chlorhexidine, CHX-HMP nanoparticle
Introduction: Inflammation associated with insertion of orthodontic miniscrews (OMS) may lead to their failure, therefore inhibition of microbial buildup is preferable. Chlorhexidine hexametaphosphate has offered persistent, slow release of active chlorhexidine over time, and hence a good anti-microbial agent.
Aims of study: To prepare and characterize CHX-HMP antimicrobial nanoparticle for coating and characterization of the stainless steel and titanium orthodontic miniscrews.
Materials and Methods: Suspension of 5 mM CHX-HMP nanoparticles were prepared. The formulated suspension was subjected to examination by AFM and FTIR. Sterilized miniscrews were immersed in the prepared suspension for half a minute, then inserted in deionized water for 10 seconds to eliminate any unbound material and then left to dry in air for at least 1 hour. The OMSs were examined by using SEM and FeSEM.
Results: The AFM micrographs displayed that the characterization of nanoparticles expressed a relative homogeneity in terms of particle size and in their topographical distribution with the regular shaped particles being well aligned vertically with mean particles size 45.2 nm. FTIR showed the presence of C=O bond in chlorhexidine digluconate and its absence in the mixed nanoparticles indicate the replacement of gluconate by hexametaphosphate. SEM and FeSEM showed that all coated OMS (stainless steel and titanium) revealed nanoparticles of spherical shape with perfect homogenous distribution with no agglomeration meaning that the coating of OMS with the prepared colloidal suspension have a good dispersion of nanoparticles.
Conclusion: OMS could be coated with antimicrobial CXH-HMP nanoparticles to assist reducing infection associated with the insertion of OMS.
How to Cite
Copyright (c) 2022 Selma Merza Hasan Al-Mousawi, Professor Akram Faisal Alhuwaiz
This work is licensed under a Creative Commons Attribution 4.0 International License.
which allows users to copy, create extracts, abstracts, and new works from the Article, alter and revise the Article, and make commercial use of the Article (including reuse and/or resale of the Article by commercial entities), provided the user gives appropriate credit (with a link to the formal publication through the relevant DOI), provides a link to the license, indicates if changes were made and the licensor is not represented as endorsing the use made of the work. The authors hold the copyright for their published work on the KMJ website, given that KMJ is responsible to appreciate citation for their work, which is released under CC-BY-4.0 enabling the unrestricted use, distribution, and reproduction of an article in any medium, provided that the original work is properly cited.