Evaluation of the antifungal and anti-hyperthyroidism efficacy of copper(II), nickel(II), cobalt(II) and zinc(II) complexes with thiourea derivatives.

Abstract

         Anew ligand N-((3,5-dichloropyridin-2-yl)carbamothioyl) pivalamide (L²)  was synthesized by reaction of benzoyl isothiocyanate with 2-Amino-3,5-dichloropyridine by using acetonitrile as a solvent , The ligand was characterized by elemental analysis apparatus , FT-IR , ¹³C,¹H-NMR spectra , UV-Visible, , some transition metals complexes(Co , Ni , Cu , Zn ) of this ligand was prepared and characterized by FT-IR , UV-Visible spectra , conductivity measurements , magnetic susceptibility ,From results the proposed molecular structure for these complexes as obtained , the following formula where M⁺² = Co , Cu , Ni , Zn [M :L²] [1 :1] Tetrahedral and [M:L²] [1:2] Octahedral . The biological activity of the prepared compounds was measured and tested as antifungals against (Candida albicans, Aspergillus Niger) and using DMSO as a control solution The results showed that the prepared compounds possess antifungal activity at different concentrations, The effectiveness of the prepared ligands and their complexes with Zn(ll) ions were studied as anti-elevation of T3 and T4 thyroid hormones induced by thyroxine, and the results showed a decrease in T3 and T4 hormones after (20) days of taking these compounds.