Reaction of Dihydroprimidine compounds containing a Styrene group with acetyl ketene intermediate

Abstract

We present the synthesis of new acetoacetylated pyrimidine derivatives in this work. These chemicals were produced via acetoacetylation of pyrimidine precursors in a two-step of chemical events. First step we presents the successful synthesis of pyrimidine derivatives through catalyst-free methods. by utilizing specific reaction conditions, we were able to achieve efficient synthesis without the need for traditional catalytic agents. the absence of catalysts in the reaction not only simplifies the process but also reduces potential side reactions and environmental impact.  The compositions of all newly created compounds are investigated utilizing spectroscopic methods like ¹H and ¹³C NMR.  The possible biological activities of the synthesized pyrimidine derivatives were assessed, and preliminary findings suggest promising uses in medicinal chemistry. To fully understand their therapeutic potential and mode of action, more research is being conducted.