Toxicity of CaO Nanoparticles effect on Haematology and Histopathology of male Rabbits

Authors

  • Rana Ismaeel Khaleel Department of Physics, College of Science, Mustansyriah University, Baghdad, Iraq
  • Asmaa Hadi Mohammed Department of Physics, College of Science, Mustansiriyah University, Baghdad, Iraq .

Keywords:

Calcium oxide nanoparticles, Toxicity, Ld50

Abstract

Calcium oxide (CaO) nanoparticle (NP) was synthesized by a simple chemical method. The CaONPs were characterized by X-ray diffraction (XRD), Scanning Electron Microscope (SEM) analysis, and UV-absorption spectral studies. The average crystallite size was found to be ≈36nm and the band gap energy of the CaO nanoparticle was 1.9 eV. Toxicity tests were performed on adult rabbits dosed with compound CaONPs for a period of (3 weeks). Areas of necrosis, hemorrhages, and degenerations were seen histopathologically in the kidney, and liver after 3 weeks of administration of CaONPs, the data of hematology obtained was statistically evaluated using Finney’s Probit Analysis and the Toxicity test performed revealed that the Ld50 value was 0.5ml/kg. This study found that an increase in the proportion of calcium oxide in the blood leads to damage to the organs, like the liver and kidneys that are responsible for filtering the blood.

DOI: http://dx.doi.org/10.31257/2018/JKP/2021/130202

Downloads

Download data is not yet available.

Downloads

Published

2021-06-10

How to Cite

Ismaeel Khaleel , R., & Hadi Mohammed, A. (2021). Toxicity of CaO Nanoparticles effect on Haematology and Histopathology of male Rabbits. Journal of Kufa-Physics, 13(02), 9–16. Retrieved from https://journal.uokufa.edu.iq/index.php/jkp/article/view/9755