Effect of Insulin Level on Recurrent Pregnancy Loss

Abstract

Aims of the study: To find the relationship between rise plasma insulin level in women with recurrent pregnancy loss at different gestational age.

Methodology : A case control study done in Al Zahraa teaching hospital in Al-Najaf city in the first of February to the first of October in 2014 of 160 women divided in two groups . We estimate fasting serum insulin hormone in samples of women with recurrent pregnancy loss at different trimester (as a case group) and healthy pregnant women at the end of 3rd trimester (as a control group). The estimation of recurrent pregnancy loss in women at different trimester is associated with endocrine abnormalities where serum insulin level increase in a different way compared with normal healthy pregnant women.

Results: We found the level of insulin hormone was high in women with recurrent pregnancy loss especially in the 1st trimester, therefore there is significant difference in insulin level in 2nd trimester compared to the 1st trimester while it is not significant between 1st and 3rd trimester, the number of women who lost their pregnancy during the 1st trimester was higher than those losing during other trimesters.

Conclusion: Current study showed that, in women with recurrent pregnancy loss, fasting insulin level is high compared with normal healthy pregnant women.

Recommendations: We recommend that measuring fasting insulin level is useful in all women with recurrent pregnancy loss The use of insulin sensitizing agent (metformin) and decrease body weight with regular daily exercise before embarking in pregnancy