The Application of ImmunohistoChemical Markers for Diagnosis, Classification and Grading of Neuroendocrine Tumors

Kaswer Musa Al-Turaihi; Roaa hameed Al-Waidh

doi:10.36321/kjns.vi20143.2767

Authors

Kaswer Musa Al-Turaihi University of Kufa
Roaa hameed Al-Waidh University of Kufa

DOI:

https://doi.org/10.36321/kjns.vi20143.2767

Keywords:

neuroendocrine tumor , chromogranin A

Abstract

objectives: To study the sensitivity of Chromogranin A in the diagnosis of neuroendocrine tumors from various locations in the body and its association with clinicopathological parameters like site and grade of tumors .

Methodology: This study is conducted in the Department of Pathology, Faculty of Medicine, University of Kufa from January - October 2013. A total of 50 patients with neuroendocrine tumors from different locations. their ages ranging between 22-80 years with a mean age of 48.3 years. Two step Envision TM flex method was employed for immunohistochemical detection of ki67 antigen (MIB -1) and Chromogranin A .

Results: Main site for patients with neuroendocrine tumors included in this study is gastroenteropancreatic system and there is female predominance, from 50 patients 44 (88%) cases was positive for Chromoranin A expression , there was no significant differences in expression of the Chromogranin A with location and grade of tumors (P value >0.05)

Conclusion: Chromogranin A is highly sensitive marker in diagnosis of neuroendocrine tumors irrespective to tumors location and tumor grade .

Recommendation: We advise to use Chromogranin A immunohistochemical marker as a main marker in diagnosis of neuroendocrie tumors in addition to that this marker can be used as target for new modality in tumor therapy .