The relationship of Heat Shock Protein-70(HSP-70) and toxoplasmosis among women with abortion

Abstract

Background: Toxoplasmosis is a wide spread disease in our society, moreover it plays an important role in causation of abortion in pregnant women.

Objectives: The present study was carried out to evaluate the role of Heat Shock Protein-70 (HSP-70) in the immune response against infection with Toxoplasma Gondi among women with abortion.

Methodology: The present study was carried out on (35) women, all of them having abortion and proved by confirmatory tests that they have an active form of toxoplasma infection. It also included twenty apparently healthy women as a control group. The patients were between 15 to 50 years of age, blood samples were collected of them during the period between May 2010 to May 2011. The Cytokines that were measured among studied groups by ELISA technique included HSP-70,Interleukin-10(IL10), Gamma Interferon (IFNγ) and Interleukin-12(IL-12), thereafter cytokines were premeasured after receiving complete course of treatment.

Results: The study showed a high significant increase in serum level of HSP-70 in patients with IgM seropositivity (4.138pg/ml) when compared with serum levels in control and post treated groups (1.990pg/ml, 1.015pg/ml) respectively. It was also found that there was a concomitant increase in serum level of HSP-70 and serum level of both IFNγ and IL-12 in the early stage of acute infection (19.023, 81.292) respectively